Laboratory Supports

Instruments Based Laboratory Supports:

Instruments/Techniques/Assay Applications
Flow-cytometer
  • Any kind of immune-fluorescence based expression of surface and/or internal markers in blood, HSCs, stem or other cells.
  • Immuno-phenotyping
  • Protein expression
  • RNA-protein expression simultaneously (Prime-flow RNA assay)
  • HLA typing
  • Beads basis cytokines measurement in plasma or serum
  • Ligand-receptor interaction study
  • Receptor-occupancy study
  • Cell cycle, cell proliferation, DNA-RNA quantification
  • Mitochondrial polarization/depolarization, mass, calcium content, mPTP pore, lysosomal MMP
  • DNA damage and apoptosis (AnnexinV/PI
LCMS/MS, MALDI-MS ESI-LC-MS and GCMS
  • Pure components analysis (MASS), Metabolic profiling of biological samples.
HPTLC,HPLC, UPLC
  • Analyte detection in plant and animal samples
  • Pharmacokinetics

X-Ray Diffraction System for Powder Thin Films with low temperature

XRD at Variable temperature

Protein Crystallization Lab. For XRD

X-Ray Diffractometer (XRD) for Macromolecules & Proteins
  • Scan at different temperatures
  • Variable temperature powder X-ray diffraction to determine the thermal expansion coefficient of solid magnesium oxide (Mgo) is presented.
  • Crystals suitable for crystallographic studies, the macromolecule (e.g. protein, nucleic acid, protein-protein complex or protein-nucleic acid complex) must be purified to homogeneity, or as close as possible to homogeneity.
EDXRF/WDXRF
  • Semi quantitative analysis
Nuclear Magnetic Resonance (NMR) 500MHz and Spectrometer with solid state attachment (CPMAS)
  • 1H1 , C13 and Phosphate based
  • 2D experiments
PCR, RT, qRT-PCR
  • Gene expression
  • Thermal shift assay (Protein-ligand interaction)
Time Resolved Flurescence spectrometer (TRFS) Spectrophotometer, Spectrofluorometer and Chemiluminescence
  • Any kind of enzymatic assays
  • ELISA
  • Cytokine detection
Bright field, phase contrast, stereozoom, Fluorescence microscopy and confocal imaging Live Cell Confocal Microscope Combined Confocal Raman- AFM Microscope
  • Structural changes determination in cellular level, quantification and protein association.
Surface Plasmon Resonance (SPR) Spectrometer
  • To analyze nucleic acid-protein interactions
Isothermal titration calorimetry (ITC)
  • Binding affinity
Circular Dichroism (CD) Spectrometer
  • Circular Dichroism (CD) is very sensitive to the secondary structure of polypeptides and proteins.
  • Alpha helix, parallel and antiparallel beta sheet, turn, and other.
Quartz Crystal Microbalance(QCM)
  • A quartz crystal microbalance (QCM) measures a mass variation per unit area by measuring the change in frequency of a quartz crystal resonator.
Physical Property Measurement System (PPMS)
  • The PPMS is an automated low-temperature and magnet system for the measurement of material properties like specific heat, magnetic AC and DC susceptibility and both electrical and thermal transport properties (like Hall Effect, thermoelectric figure of merit and Seebeck Effect).
Proximity ligation assay (PLA)
  • Protein-protein localization (<40 nm)
FTIR-Raman
  • Molecule - molecule interaction study
Transimission Electron Microscope (TEM)/ Scanning Electron Microscope (SEM)
  • Structural changes determination in cellular level and quantification
In-vivo optical imaging
  • Cell tagging with fluorophore, Cell migration, drug distribution
Bitplane:Imaris, metamorph and Image J
  • Image analysis and Z stacking/3D construction
Hematology
  • Whole blood profiling
Immuno-Histology
  • Protein expression and cellular integrity

Experiments Based Laboratory Support:

Experiments Based Techniques Applications
In-vitro cell culture
  • Biological assays
In-vivo
  • Any kind of animal experiments we conduct in C57 BL6, balbC and SD Rat.
Microbial studies
  • Antibiotics sensitivity test
  • Species identification
  • Biochemistry based test
  • Microbial infection study in animal system
  • Immunological study
Proteomics

Almanac Life Science India Pvt. Ltd. provides proteomics based services.

  • Cloning, Expression and Purification of recombinant proteins
  • Characterization
  • Antibody generation
  • Immunoprecipitation
  • Post-translational modifications (PTMs), including phosphorylation, deamidation, N-glycosylation, ubiquitination, amino acid mutations, acylation and N-/C-terminal sequence determination
  • Peptide finger printing
  • iTRAQ
Custom Synthesis

Almanac Life Science India Pvt. Ltd. provides custom synthesis services.

  • Peptide synthesis
  • Gene synthesis
  • siRNA synthesis
Pharma Supports

Almanac Life Science India Pvt. Ltd. provides Pharma support services.

  • Drug formulation
  • Stability test
  • In-vitro drug release kinetics
  • In-vivo Pharmacokinetics
  • Toxicity Assay (In-vivo and In-vitro)

Product Development Services

  • Preformulation studies
  • Formulation development
    • Generic products (all types of dosage forms)
    • New products (all types of dosage forms)
  • Nanopharmaceutical development
  • Cosmetic formulation and food product development
  • Dissolution method development
  • Permeation characterization studies
  • Product characterization studies
  • All types of formulation stability testing
  • Formulation reverse-engineering

Clinical Services

  • Pharmacokinetic-Pharmacodynamic Studies
  • Bioavailability-Bioequivalence studies
  • Gamma-Scintigraphy Imaging studies
Computational Biology Supports

Almanac Life Science India Pvt. Ltd. provides quality level computational supports for all kinds of biological applications.

  • Functional genomics analysis for plants, animals and clinical study
  • Expression profiling (Genes and Proteins) for all kinds of raw data set irrespective of the platforms.
  • Network level understanding (Genes and Proteins)
  • Computational chemistry
Next Generation Sequencing (Sequencing & Analysis)

An NGS technology is used to generate significant amounts of output data. Once the sequence is aligned to a reference genome, the data is analyzed in an experiment-specific fashion and visualized. Almanac Life Science India Pvt. Ltd. provides sequencing and analysis services.

  • Whole genome sequencing data analysis
  • Whole genome de novo assembly
  • Genome annotation
  • Variant annotation
  • SNP/Indel calling & mapping
  • Genome Wide Association Studies (GWAS)
  • Comparative genomics
  • Genotyping by sequencing data analysis
  • Methylation data analysis
  • miRNA, siRNA, sequencing data analysis
  • Small RNA annotation & mapping
  • RNA sequencing data analysis
  • De novo transcriptome assembly & analysis
  • Transcription annotation & mapping
  • Gene expression analysis
  • Metagenomics data analysis
  • 16S ribosomal RNA (rRNA) sequencing data analysis.
Microarray Analysis

Almanac Life Science India Pvt. Ltd. provides high quality microarray services like Transcriptomics, Genomics & Epigenetics for microarray experiments

Transcriptomics Microarray

  • MicroRNA Expression Profiling Microarray Service
  • Gene Expression Profiling Microarray Service
  • LncRNA Microarray Service

Genomics Microarray

  • SNP Microarray Service
  • CGH Microarray Service

Epigenetics Microarray

  • ChIP-on-chip Service
  • DNA Methylation Microarray Service
Theoretical and Computational Chemistry

Theoretical/computational chemistry is the branch of chemistry which uses the principle of chemical science that facilitates in solving various chemical problems which are somehow difficult to get from experiments. It also helps to design new molecules/complexes and provides clue to experimentalists.

  • To understand electronic structure of metal complexes.
  • Magnetic exchange coupling.
  • Spectroscopic parameters (EPR, Mossbauer, Infrared, UV-visible spectroscopy etc).
Statistic Services

Almanac Life Science India provide a wide range of statistic based analysis and services

  • Descriptive Statistical Analysis
  • Parametric and nonparametric statistics
  • Advanced statistical analysis such as ANOVA, ANCOVA, MANOVA, & MANCOVA
  • One-Way and Two-Way Repeated Measure ANOVA
  • Correlation/Regression models
  • Principle Component Analysis
  • Design of Experiments (DoE)
  • Quality by Design (QbD)
  • Multivariate statistical analysis
Food and Cosmetics Product Testing

Almanac Life Science India Pvt. Ltd. is an independent analytical, research and development laboratory, functioning in the field of edible oils, oilseeds, oil cakes, oil based products, spices, food items & animal feed.

Almanac Life Science India Pvt. Ltd. provides Food & Cosmetic testing services, act as advice & consultancy bureau, and undertakes contractual research projects. Our lab is fully equipped with the HPLC, GC, LC-MS, ELISA, PCR, RT-PCR machines and has well experienced technical staff.

We follow AOAC, Codex, BIS, FSSAI and OECD guideline for testing

Samples We Test:

  • Edible Oil, Fats & Oil Products like Vanaspati, Margarine, Bakery fat etc.
  • Milk and dairy products
  • Spices and Condiments, Coffee, Tea etc.
  • Animal Feed
  • Raw and processed fruits and vegetables
  • Cereals and pulses
  • Sugar and confectionery, Honey
  • Food additives
  • Alcoholic and non-alcoholic beverages
  • Meat and meat products
  • Egg and poultry products
  • Marine products
  • Cosmetic products

Parameters We Test:

  • Aflatoxin/Mycotoxin
  • Food Allergensâ€?Gluten, Soy, Casein, Peanut, Almond etc.
  • Antibioticsâ€?Tetracycline, Chloramphenicol, Sulfonamide etc
  • Vitamins
  • Pesticides, Insecticides
  • Heavy Metals
  • Dyes & Added color
  • Histamine, Melamine, Malachite green
  • Complete Nutritional analysis
  • Complete Oil testing including Sterol, Tocopherol, Fatty Acid Composition, Trans fatty acid, Tocopherol, Oryzanol etc.
  • Food pathogen: E.coli, Listeria, Salmonella, Yeast & Molds etc.
  • GMO materials
  • Rapid testing services is also available for E.coli, Listeria and Salmonella in food samples

Cosmetics & Chemical Products Testing:

  • Skin Irritation testingâ€?In-vitro testing as per OECD guideline 439
  • Skin Corrosion testingâ€?In vitro testing as per OECD guideline 431
Content Writing in Biological/Chemical, Physical Sciences

We provide a wide range of end-to-end solutions, training and consultation to both academia and industry for the following:

  • Bioinformatics based Manuscript writing.
  • Bioinformatics based thesis writing (150-200 pages).
  • Experimental based manuscript writing.
  • Experimental based thesis writing (150-200 pages).
  • Review Article preparation (Biological, Chemical and Physical sciences)
  • Book publishing (4-6 months).
  • Journal sp. Issue publishing (2-4 months).
  • Book Chapters according to topic (20-30 pages).
  • Master's thesis/dissertation writing (50-70 pages).
  • Proposal/project writing in the field of Biological sciences.

Industry services

  • Product development report writing
  • Product information leaflet writing
  • Techno-marketing chart writing
  • Preclinical report writing
  • Clinical report writing

Regulatory services

  • Monograph writing
  • Query handling
  • Report compilation

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